Description
Recombinant human fusion STRN (1-137a.a., exons1-3) -ALK (1058a.a.-end, exons20-29) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number of STRN is NM_003162 and ALK is NM_004304.
Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene, resulting in the expression of novel chimeric ALK proteins with transforming properties. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types (1). A fusion protein of STRN-ALK has been reported in a non-small cell lung cacner due to resistant to Alectinib (2)